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Headshot of John DeSpain, FAAD, MD, board-certified dermatologist at Forefront Dermatology

John DeSpain, MD, FAAD

Board-Certified Dermatologist
5.0/5 Google Reviews
Schedule an appointment
Dr. John DeSpain is a highly skilled and trusted dermatologist with over 30 years of practice in the field. As a board-certified dermatologist, Dr. DeSpain is dedicated to providing comprehensive medical, surgical, and cosmetic dermatology services to his patients. His commitment to understanding each patient's unique needs and concerns sets him apart in this fast-paced world.

With a focus on patient-centered care, Dr. DeSpain believes in collaborating with his patients to create practical, safe, and effective treatment plans. He recognizes the importance of staying up to date with the latest advancements in dermatology and utilizes a wide range of treatment options to address various skin disorders.

Dr. DeSpain offers a comprehensive range of services:

  • Skin cancer detection and treatment
  • Treatment for acne, rosacea, psoriasis, eczema, rashes, warts, and more
  • Chronic and complex skin conditions
  • Skin rejuvenation treatments including Botox®, filler, and removal of unwanted growths or moles
Having enjoyed weekends at the lake for over two decades, Dr. DeSpain is excited to call this area his home and be active in the community.

Medical School
University of Missouri - Columbia, MO

Dermatology Residency
University of Missouri - Columbia, MO

Dermatopathology Fellowship
University of Colorado - Denver, CO

Schedule an appointment with Dr. DeSpain

Forefront Dermatology clinic exterior in Osage Beach, MO
Forefront Dermatology

5721 Osage Beach Parkway Ste 100
Osage Beach, MO 65065

(573) 302-4696

Medical dermatology

Skin cancer treatment

Cosmetic dermatology

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What Dr. DeSpain's patients have to say:

Google Reviews • Forefront

So appreciative of the excellent customer service! Dr DeSplain and his team addressed my urgent need that thankfully turned out to be not urgent. His advice and guidance is appreciated and will be followed. What a terrific team! Thank you!

Google Reviews • Forefront

Dr. DeSpain and staff are very nice and efficient. If medicine that was prescribed is not working as well as Dr. DeSpain expected it, he does not hesitate to try something else. He also makes sure that side effects of the medicine stays in check.

Google Reviews • Forefront

Friendly staff (MA and office staff). I took the time to pre-register online and was called in at the time of my appointment. Dr. DeSpain is friendly and clearly explains the diagnosis and course of action. Took the time to answer questions. This is a repeat visit to this clinic for me.

Google Reviews • Forefront

Great doctor and very personal in his approach. Listens quite intensely to your questions and comes up with stepped solutions.

Google Reviews • Forefront

Completely painless and quick. Always professional.

Google Reviews • Forefront

Dr. DeSpain is very friendly and competent. He takes the time to explain what he is doing and adjusted my appointments when we discussed my plan for my care. What really impressed me is how he treats and educates his staff, treating them with respect and kindness. Did I mention that he is also an excellent Dr. could not be more pleased with my care.

Google Reviews • Forefront

I am glad to have chosen this dermatologist. He is very friendly and knowledgeable.

Google Reviews • Forefront

They are very personable and knowledgeable. You get right in and out in a very short time. Even though we only go once a year they seem to remember us. It is the place to go for dermatology.

Google Reviews • Forefront

Excellent Doc and well run office !! Organized and efficient

Google Reviews • Forefront

Staff and Dr DeSpain very courteous and efficient! Got in, no wait. Out very quickly!

Google Reviews • Forefront

I arrived early and was called to the back in just a few minutes. Everyone was pleasant and helpful. This visit was short and sweet which is nice sometimes!

Google Reviews • Forefront

Very knowledgeable to my needs.

Google Reviews • Forefront

All staff and Doctor were timely, thorough and kind.

Google Reviews • Forefront

All staff and Doctor were timely, thorough and kind.

Google Reviews • Forefront

Very professional, very timely, made you feel very comfortable.

Google Reviews • Forefront

Great experience with Dr. DeSpain and the entire staff. Doc is very knowledgeable and approachable. He fixed my issue. Don’t hesitate to book an appointment.

Google Reviews • Forefront

Dr. DeSpain has a wonderful bedside manner & is very personable. He is efficient in identifying my needs & provide me education & a solution. His support staff is very kind & able to answer all questions that I had.

Google Reviews • Forefront

A great place that gave quick and prompt service. I would recommend for any dermatology needs

Google Reviews • Forefront

Dr. Despain performed minor surgery on my thigh recently and it has healed very well. He was very pleasant and I experienced no pain.

Google Reviews • Forefront

1000/10! Dr Despain is my favorite doctor I've ever had. He's gone above and beyond for me to treat my severe systemic eczema. He's a one of a kind doctor, who is extremely knowledgeable and caring. I am truly grateful for the treatment plan I've received from Dr Despain and his wonderful, very responsive, equally as helpful staff! THANK YOU!!