John DeSpain, MD, FAAD
Board-Certified Dermatologist
5.0 /5
203 reviews

John DeSpain, MD, FAAD

Dr. John DeSpain is a highly skilled and trusted dermatologist with over 30 years of practice in the field. As a board-certified dermatologist, Dr. DeSpain is dedicated to providing comprehensive medical, surgical, and cosmetic dermatology services to his patients. His commitment to understanding each patient’s unique needs and concerns sets him apart in this fast-paced world.

With a focus on patient-centered care, Dr. DeSpain believes in collaborating with his patients to create practical, safe, and effective treatment plans. He recognizes the importance of staying up to date with the latest advancements in dermatology and utilizes a wide range of treatment options to address various skin disorders.

Dr. DeSpain offers a comprehensive range of services:

  • Skin cancer detection and treatment
  • Treatment for acne, rosacea, psoriasis, eczema, rashes, warts, and more
  • Chronic and complex skin conditions
  • Skin rejuvenation treatments including Botox, filler, and removal of unwanted growths or moles

Having enjoyed weekends at the lake for over two decades, Dr. DeSpain is excited to call this area his home and be active in the community.

Osage Beach

5721 Osage Beach Parkway
Osage Beach, Missouri 65065
Tel:(573) 302-4696
BOOK APPOINTMENT
Especially in this fast-paced world, it is critical to take time to understand each patient’s unique needs and concerns. We have many options today to treat skin disorders, and we can work together to create a practical, safe, and effective care plan.
- John DeSpain, MD, FAAD
google
5.0/5
• Forefront Dermatology
I had a very positive experience with Dr. DeSpain. He was approachable, thorough in addressing my questions about a skin issue, and took the time to explain everything clearly. The process felt seamless, and my prescription was ready promptly after the visit. I would highly recommend his and his staffs care.
google
5.0/5
• Forefront Dermatology
Dr Despain and staff are super punctual and very personable. Great experience and will be back again next time!
google
5.0/5
• Forefront Dermatology
Dr DeSpain is efficient, understanding, willing to explain. My confidence in him is such that I drove to Columbia, Jefferson City and now Osage Beach to continue to receive his service.
google
5.0/5
• Forefront Dermatology
Dr DeSpain was so helpful in taking care of my warts. He was educational as we'll. His assistant Lindsey was helpful as well.
google
5.0/5
• Forefront Dermatology
Great doctor and office. Would recommend him. I'm disappointed he doesn't take my insurance so for 2025 looking for new dermatologist.
google
5.0/5
• Forefront Dermatology
He was considerate of my concerns and made me feel at ease with his professional demeanor.
google
5.0/5
• Forefront Dermatology
I felt so comfortable in the office.I was treated so nice and everyone was nice.Dr DeSpain was GREAT I understood all he said.I was not in any pain while he removed something from my ear and it’s like 10 hours later and still no pain.His bedside manner is terrific.Would highly recommend.
google
5.0/5
• Forefront Dermatology
The office is a nice facility. Dr. DeSpain is great. Just wish I lived closer.
google
5.0/5
• Forefront Dermatology
Very friendly & professional
google
5.0/5
• Forefront Dermatology
My initial visit to Dr DrSpain and this office. The experience was top notch, from the referral and scheduling to the exam and diagnosis. Explanations were clear and understandable without medical jargon. The staff exhibited care and concern with even my minor issue. I was very impressed.
Education

Medical School:

University of Missouri – Columbia, MO

Dermatology Residency:

University of Missouri – Columbia, MO

Dermatopathology Fellowship:

University of Colorado – Denver, CO

Certificates
American Board of Dermatology
American Board of Dermatopathology
Professional Memberships
American Academy of Dermatology
Missouri Dermatologic Society
Missouri State Medical Association

*Age Restriction


For patients scheduling who are under 18 years of age (19 in Alabama) please make sure you have permission from your parent or legal guardian to schedule this appointment.  Your parent or legal guardian must accompany you on your initial visit and on certain subsequent visits to provide appropriate informed consent.
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